Prostate cancer
Conditions
Interventions
Observation group:None
Sponsors
Beijing Hospital
Eligibility
Sex/Gender
Male
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-80 years, diagnosed with prostatic acinar adenocarcinoma by biopsy; 2. High-risk/locally advanced disease (meeting any of the following): PSA >20 ng/ml, or Gleason score >=8, or clinical stage >=T3a, or imaging suggesting pelvic lymph node metastasis (cN1) but no distant metastasis (M0); 3. Completion of 6 months of neoadjuvant ADT; 4. Availability of prostate MRI examinations both before prostate biopsy and at the completion of neoadjuvant ADT; 5. Good general health condition with no significant surgical contraindications; 6. Ability to comply with regular follow-up.
Exclusion criteria
Exclusion criteria: 1. Presence of distant metastasis (M1); 2. Biopsy pathology indicating non-prostatic adenocarcinoma, or prostatic adenocarcinoma mixed with other histologic types (e.g., neuroendocrine/small cell carcinoma components, ductal adenocarcinoma, etc.); 3. Previous treatment for prostate cancer including ADT and/or chemotherapy, pelvic radiotherapy, or prostate surgery; 4. Coexistence of severe autoimmune diseases, severe cardiovascular or cerebrovascular diseases, severe thromboembolic diseases, severe pulmonary diseases, psychiatric disorders, or other uncontrolled malignancies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Biochemical or radiographic recurrence; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pathological complete response;Minimal residual disease ;Imaging Performance;Surgical quality; | — |
Countries
China
Contacts
Public ContactMing Liu
Beijing Hospital
Outcome results
None listed