Bulky (lesion maximum diameter >= 5 cm) malignancies
Conditions
Interventions
Treatment group:LRT radiotherapy (45 Gy/3fx, alternate day irradiation) can be combined with conventional radiotherapy or immunotherapy subsequently
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years; 2. Tumor volume is large (any dimension >= 5 cm); 3. Or requirement for rapid symptom relief; 4. Or requirement for tumor volume reduction as induction therapy prior to palliative-dose external beam radiation therapy (EBRT) for locally advanced tumors ineligible for standard EBRT; 5. Eligible for immunotherapy; 6. And expected survival time exceeding 3 months; 7. Absolute neutrophil count >= 1.5×10^9/L, hemoglobin >= 90 g/L, and platelet count >= 100×10^9/L; 8. For patients with liver cancer, ALT/AST <= 2.5 times the upper limit of normal (ULN), and bilirubin <= 1.5 times ULN; 9. The patient must sign the informed consent form and be willing and able to comply with the study visits, treatment regimens, and other requirements specified in the protocol.
Exclusion criteria
Exclusion criteria: Those who do not meet the above inclusion criteria will not be included in the group
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Objective Response Rate (ORR; | — |
Secondary
| Measure | Time frame |
|---|---|
| Toxic and side effects of OAR;Progression Free Survival, PFS;Overall survival, OS; | — |
Countries
China
Contacts
Public ContactXiao Jianghong
West China Hospital, Sichuan University
Outcome results
None listed