Perioperative anxiety
Conditions
Interventions
Dexmedetomidine group:Nasal spray of dexmedetomidine
Control group:Nasal spray of normal saline
Sponsors
Zhengzhou Central Hospital Affiliated to Zhengzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Age of 18-65 years old (2) ASA grade I-III (3) 18.5Kg/m2 <= BMI < 30 kg /m^2 (4) patients scheduled for elective posterior lumbar discectomy, spinal canal decompression, pedicle screw internal fixation, or lumbar fusion.
Exclusion criteria
Exclusion criteria: (1) Use of opioids, nonsteroidal anti-inflammatory drugs, gabapentin, benzodiazepines, or other prescription drugs with sedative or analgesic effects within one week before surgery; (2) Alcoholism (3) history of endocrine system diseases (4) sinus bradycardia or severe arrhythmia (5) complicated with severe hypertension and severe hepatic and renal insufficiency before operation (6) mental disorders (7) preoperative use of glucocorticoids 8) Expected procedure duration more than 3 hours
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| APAIS scores of patients at the time of admission to the operating room; | — |
Secondary
| Measure | Time frame |
|---|---|
| HADS - A before surgery and on the 1st, 2nd, and 3rd days after surgery.;Incidence of anxiety from the day of surgery to 3 days after surgery;The Richards-Campbell Sleep Questionnaire scores for the night before the surgery and the night after the surgery;The quality of recovery (QoR-15) scores at 1 day and 2 days after surgery were evaluated;Time to tracheal extubation;NRS scores at rest and during movement were recorded at 2h, 12h, 24h, 48h and 72h after surgery;Cumulative opioid consumption (morphine equivalent) at 24h, 48h and 72h after surgery;Preoperative and postoperative blood cortisol ;Preoperative and postoperative inflammatory factor levels (IL-1ß, IL-6, TNF-a, IL-10);Incidence of perioperative adverse events (including severe bradycardia, severe hypotension, postoperative nausea and vomiting, anaphylaxis, and delirium);PACU stay time;length of stay; | — |
Countries
China
Contacts
Public ContactYan Wang
Zhengzhou Central Hospital Affiliated to Zhengzhou University
Outcome results
None listed