Heart failure
Conditions
Interventions
Rapid Reverse Engineering and Refactoring Group:N/A
Slow or no reverse reconstruction group:N/A
Sponsors
The First Hospital of Jilin University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age >= 18 years; 2.Clinical diagnosis of heart failure meeting the criteria of the *2022 AHA/ACC/HFSA Heart Failure Management Guideline; 3.Initiation or first optimization of Guideline-Directed Medical Therapy during the index hospitalization, including at least two drug classes among: beta-blockers, renin-angiotensin system inhibitors, mineralocorticoid receptor antagonists, and SGLT2 inhibitors; 4.Baseline echocardiography (performed prior to or concurrently with GDMT initiation/optimization) with standardized measurement (preferably Simpson‘s biplane method) confirming a left ventricular ejection fraction (LVEF) =30 days after initiation/optimization and discharge), with both examinations occurring after the efficacy observation start point (3 months post-stabilization) and an inter-examination interval of >=1 month;
Exclusion criteria
Exclusion criteria: 1.Missing or poor-quality echocardiographic data at baseline or during follow-up precluding accurate measurement of LVEF and left ventricular dimensions; 2.Conditions severely interfering with cardiac structure and function assessment (including but not limited to: severe valvular disease without intervention, acute myocardial infarction within 3 months prior to enrollment, constrictive pericarditis, history of heart transplantation or left ventricular assist device implantation); 3.Severely missing clinical follow-up data, preventing assessment of GDMT adherence; 4.End-stage renal disease with long-term dependence on renal replacement therapy; 5.Pregnancy or lactation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Left Ventricular Reverse Remodeling Trajectory Classification; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart failure readmission;Composite endpoint (Heart failure readmission or All-cause mortality);All-cause mortality; | — |
Countries
China
Contacts
Public ContactWang yushi
The First Hospital of Jilin University
Outcome results
None listed