postoperative analgesia
Conditions
Interventions
High pain sensitivity / dexmedetomidine group:At the induction of anesthesia, a loading dose of dexmedetomidine 1 µg/kg will be administered by intravenous infusion over 10 minutes, followed by a cont
High Pain Sensitivity/Saline Group:At the induction of anesthesia, a loading dose of normal saline, identical in appearance, volume, and infusion rate to the study drug, will be intravenously infused
Low pain sensitivity / dexmedetomidine group:At the induction of anesthesia, a loading dose of dexmedetomidine 1 µg/kg will be administered by intravenous infusion over 10 minutes, followed by a conti
Low Pain Sensitivity/Saline Group:At the induction of anesthesia, a loading dose of normal saline, identical in appearance, volume, and infusion rate to the study drug, will be intravenously infused o
Sponsors
The First Affiliated Hospital of Dalian Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 18 to 75 years who are scheduled to undergo total knee arthroplasty due to osteoarthritis; 2. ASA classification I–II; 3. Completion of PSQ assessment before surgery; 4. Meeting surgical indications, able to tolerate general anesthesia, and will not use a postoperative analgesic pump; 5. Signing the informed consent form.
Exclusion criteria
Exclusion criteria: 1. History of chronic opioid use; 2. Severe cardiovascular dysfunction, such as sick sinus syndrome, second-degree or third-degree atrioventricular block, bradycardia (heart rate <50 bpm); 3. Severe liver and kidney dysfunction (albumin <30 g/L, glomerular filtration rate <30 mL/min/1.73m^2); 4. Individuals with psychiatric disorders who cannot cooperate; 5. Individuals with multiple neuropathies or diabetic neuropathy; 6. Allergic to dexmedetomidine.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain score at rest; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to first request for analgesic medication and total analgesic consumption;Pain score during activity;Sedation Score;Sleep Quality;Quality of Recovery Score;Incidence of Adverse Events; | — |
Countries
China
Contacts
Public ContactWu Ping
The First Affiliated Hospital of Dalian Medical University
Outcome results
None listed