Perioperative neurocognitive disorders
Conditions
Interventions
Group C:During the surgical procedure, intravenous infusion of 0.4-2.4mg/kg/h cyclosporine and 0.3-0.5 µ g/kg/min remifentanil was administered
Group P:During the surgery, intravenous infusion of 4-6mg/kg/h propofol and 0.3-0.5 µ g/kg/min remifentanil was administered
Sponsors
Inner Mongolia Medical University Affiliated Hospital
Eligibility
Sex/Gender
All
Age
60 Years to 90 Years
Inclusion criteria
Inclusion criteria: (1) Age >= 60 years old; (2) American Society of Anesthesiologists (ASA) classification II-III; (3) Patients undergoing elective laparoscopic resection of colorectal tumors under general anesthesia; (4) Voluntarily participate in this clinical trial and sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Previous history of drug dependence, such as antipsychotic drugs, anti anxiety drugs, antidepressants, stimulants, and opioid drugs; (2) History of mental or psychological illness in the past; (3) History of neurological disorders that affect cognitive function, such as Alzheimer's disease (AD), vascular dementia, and any other form of dementia; (4) Preoperative Montreal Cognitive Assessment (MoCA) score<26 points; (5) Unable to understand the evaluation scales related to this study or uncooperative evaluators; (6) Lack of follow-up data; (7) Participated in other clinical trials within the 3 months prior to being selected for this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative delirium incidence rate;Incidence of delayed early postoperative neurocognitive recovery; | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS score ;NRS score ;Restore quality;Preoperative and postoperative C-reactive protein/interleukin-6/procalcitonin;Cerebral oxygen saturation;Mean arterial pressure/heart rate;General situation/intraoperative situation;Postoperative adverse events;Intraoperative minimum mean arterial pressure; | — |
Countries
China
Contacts
Public ContactSun Tao
Inner Mongolia Medical University Affiliated Hospital
Outcome results
None listed