Post stroke cognitive impairment
Conditions
Interventions
Left cerebral cortex injury group:None
Left subcortical injury group:None
Right cerebral cortex injury group:None
Right subcortical injury group:None
Healthy control group:None
Open-loop intervention group:Based on baseline assessment, classified by cortical/subcortical injury type, fixed-parameter TMS stimulation (1Hz or 5Hz, 80%-120% RMT) was administered to the DLPFC on t
Closed-loop regulation group:Real-time triggering of TMS stimulation based on fMRI task-state activation or EEG oscillation signals: For those with cortical injury, excitatory or inhibitory stimulatio
Sponsors
The Third Affiliated Hospital of Zhejiang Chinese Medical University
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. PSCI patients inclusion criteria : ( 1 ) In line with the diagnostic criteria in the ' Expert Consensus on Post-Stroke Cognitive Impairment Management 2021 ', and it was the first onset ; ( 2 ) MMSE score in accordance with Zhang Mingyuan et al according to the Shanghai population to develop boundaries : secondary school or above =55 points. 2. Healthy control group inclusion criteria : ( 1 ) Cognitive function is normal, no memory impairment, MMSE score 26 ~ 27 points, MoCA score >= 26 points, if the education years <= 12 years, the score plus 1 point ; ( 2 ) no history of cerebrovascular disease and brain trauma ; ( 3 ) Without hearing impairment, can cooperate with the inspection and voluntary participation. ( 4 ) The dominant hand was on the right side, with stable vital signs and no history of mental illness ; ( 5 ) Age 50-80 years old;
Exclusion criteria
Exclusion criteria: 1. Exclusion criteria for PSCI patients: (1) Having conditions such as visual impairment, hearing impairment, consciousness impairment, and severe aphasia that affect cooperation with the examination; (2) Patients with severe cardiovascular, liver, kidney and hematopoietic system diseases, etc. (3) There is a clear history of cognitive impairment caused by other reasons, such as Alzheimer's disease, Parkinson's disease, etc. (4) Those with metal implants, metal pacemakers or incomplete skulls in the brain; (5) Patients who receive treatment as prescribed or have poor compliance; (6) Patients with contraindications to transcranial magnetic stimulation; 2. Exclusion criteria for the healthy control group: (1) Having conditions such as visual impairment, hearing impairment, consciousness impairment, severe aphasia, cognitive impairment, etc., which affect cooperation with the examination; (2) Patients with severe cardiovascular, liver, kidney and hematopoietic system diseases, etc. (3) Those with metal implants, metal pacemakers or incomplete skulls in the brain; (4) Patients who receive treatment as prescribed or have poor compliance; (5) The dominant hand is on the left side. (6) Age 80 years old.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Weighted comprehensive rehabilitation effect score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment Scale (MoCA) score;Activities of Daily Living Scale (Barthel Index;The accuracy rate and reaction duration of the Stroop color Word interference Test (SCWT);The activation volume of functional magnetic resonance imaging (fMRI) and the strength of functional connectivity;The activation volume of functional magnetic resonance imaging (fMRI) and the strength of functional connectivity;TMS evoked potential (TEPs;The degree of synchronization between the energy variation of the ? band and that of the ? band; | — |
Countries
China
Contacts
Public ContactLiu wenbing
The Third Affiliated Hospital of Zhejiang Chinese Medical University
Outcome results
None listed