Postoperative depression
Conditions
Interventions
Low-dose Esketamine Group:Esketamine 0.15 mg/kg was administered intravenously during induction.
Moderate-dose Esketamine Group:Esketamine 0.3 mg/kg was administered intravenously during induction.
Sponsors
Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Elective laparoscopic urological tumor surgery; 2. ASA grade II-III; 3. Age >=65 years old; 4. Bmi18.5-27.9 kg/?.
Exclusion criteria
Exclusion criteria: 1.Severe cognitive impairment before surgery 2.Hypersensitivity and contraindications to esketamine (including patients with severely elevated intracranial pressure; patients with untreated or poorly controlled hypertension; patients with glaucoma; patients with untreated or undertreated hyperthyroidism; patients with adrenal pheochromocytoma; patients with epilepsy) 3.Complicated with severe cardiovascular diseases (e.g., myocardial infarction, heart failure, malignant arrhythmia, etc.), renal diseases (glomerular filtration rate = 2 mg/dl) 4.Geriatric Depression Scale-15 (GDS-15) score > 5 points before surgery 5.Recent administration of antidepressants or receipt of other antidepressant therapies 6.Patients with moderate to severe anemia (hemoglobin < 90 g/L) 7.A history of substance abuse, psychiatric disorders, communication disorders, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of depression within 3 days after surgery;HADS score; | — |
Secondary
| Measure | Time frame |
|---|---|
| AIS score;MMSE score;Time from the end of the operation to extubation;Perioperative propofol, remifentanil consumption;Intraoperative vasoactive drug use;The incidence of postoperative adverse reactions . . "postoperative"? , AI ;Administration of analgesic drugs within 24 hours after surgery;VAS pain score;The first time of the postoperative exhaust; | — |
Countries
China
Contacts
Public ContactGuanglei Wang
Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed