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Analysis of the Etiology and Risk Factors for Cerebrospinal Fluid Rhinorrhea following Endoscopic Endonasal Skull Base Surgery

Analysis of the Etiology and Risk Factors for Cerebrospinal Fluid Rhinorrhea following Endoscopic Endonasal Skull Base Surgery

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600117714
Enrollment
Unknown
Registered
2026-01-28
Start date
2026-02-01
Completion date
Unknown
Last updated
2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cerebrospinal fluid rhinorrhea

Interventions

Observation group:None

Sponsors

Beijing Tiantan Hospital, Capital Medical University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1.Patients who underwent endoscopic endonasal skull base surgery in the Third Ward of Neurosurgery during the period from January 2021 to December 2024, with a minimum postoperative follow-up of 3 months. 2.Patients who signed the informed consent form and agreed to participate in data collection.

Exclusion criteria

Exclusion criteria: 1.Patients with preoperative cerebrospinal fluid (CSF) leakage. 2.Patients with severe comorbidities that may affect postoperative recovery or data integrity (e.g., severe cardiac, hepatic, or renal insufficiency, malignancies, etc.). 3.Patients who were lost to follow-up. 4.Patients who failed to sign the informed consent form.

Design outcomes

Primary

MeasureTime frame
The proportion of patients with postoperative cerebrospinal fluid (CSF) leakage.;BMI;

Secondary

MeasureTime frame
The therapeutic efficacy for cerebrospinal fluid (CSF) leakage.;Postoperative recovery;age;Weight;Gender;History of hypertension;History of diabetes mellitus;History of heart disease;Smoking history;Drinking history;Imaging examination results;Blood indicators;Surgery type;Intraoperative skull base reconstruction technique used;Surgery duration;Intraoperative blood loss;Length of postoperative hospital stay;Time of onset of postoperative cerebrospinal fluid leakage;Symptoms of postoperative cerebrospinal fluid leakage;Imaging diagnosis of postoperative cerebrospinal fluid leak;Postoperative management measures;Postoperative complications;

Countries

China

Contacts

Public ContactLei Cao

Beijing Tiantan Hospital, Capital Medical University

caolei_163@163.com+86 138 1096 6230

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 7, 2026