Hypertension
Conditions
Interventions
Propofol group:During the induction and maintenance phases of general anesthesia, propofol was selected for sedation in the propofol group
the other medications (such as analgesics, muscle relaxants, and emergency rescue drugs, etc.) used in both groups for general anesthesia were kept the same except for the sedative drugs.
Remimazolam group:During the induction and maintenance phases of general anesthesia, the remimazolam group used sarazolam phosphate for sedation
the other medications (such as analgesics, muscle relaxants, and emergency rescue drugs, etc.) administered in both groups were kept the same except for the sedative drugs.
Sponsors
Baotou Central Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Patients scheduled for laparoscopic surgery under general anesthesia; 2.According to the American Society of Anesthesiologists (ASA) anesthesia classification, they are at levels II or III; 3.Body Mass Index (BMI) is 18-28 kg/m^2; 4.Patients who meet the diagnostic criteria for primary hypertension [systolic blood pressure >=140 mmHg and/or diastolic blood pressure >= 90 mmHg], are regularly receiving antihypertensive medication and have relatively stable blood pressure; 5.Patients have given informed consent, voluntarily participated in this study, and signed the anesthesia informed consent form and the subject informed consent form.
Exclusion criteria
Exclusion criteria: 1.The subjects explicitly refused to participate in this study; 2.Those who are allergic to or have contraindications to benzodiazepine drugs, opioid drugs, and other investigational drugs; 3.Those whose primary hypertension was not effectively controlled before the surgery (systolic blood pressure > 180 mmHg and/or diastolic blood pressure > 110 mmHg); 4.Secondary hypertension patients (such as renal hypertension, endocrine hypertension); 5.Patients with acute respiratory inflammation within 2 weeks and a history of unhealed condition; 6.Those with preoperative significant organ dysfunction (such as cardiac insufficiency, pulmonary insufficiency, liver and kidney dysfunction, etc.); 7.Those with a history of diabetes before the surgery; 8.Those with a history of coronary heart disease before the surgery; 9.Those who have been taking (abusing) psychotropic drugs for a long time or have cognitive dysfunction; 10.Those who have taken hormones or immunosuppressants within 3 months before the surgery; 11.Those who have participated in drug clinical trials within 3 months before the surgery; 12.Those with incomplete clinical examination data; 13.Those considered by the researchers to be unsuitable to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean Arterial Pressure (MAP);Heart rate (HR);Peripheral Oxygen Saturation (SpO2);Bispectral Index of Electroencephalogram (BIS); | — |
Countries
China
Contacts
Public ContactBai Shuancheng
Baotou Central Hospital
Outcome results
None listed