Septic Shock
Conditions
Interventions
the lactate clearance rate >=20% group:None
the lactate clearance rate < 20% group:None
Sponsors
the First Affiliated Hospital of the University of Science and Technology of China (Anhui Provincial Hospital)
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: (1) Age >= 18 years; (2) Patients requiring ICU admission due to septic shock (meeting Sepsis 3.0 diagnostic criteria); (3) Invasive hemodynamic monitoring via PiCCO is clinically indicated; (4) Patients and their families are informed and have provided signed informed consent.
Exclusion criteria
Exclusion criteria: (1) History of neck radiotherapy or surgery; (2) Deep vein thrombosis of the upper limb or internal jugular vein thrombosis; (3) Extremely unstable vital signs (e.g., requiring high-dose vasopressors to maintain blood pressure); (4) Severe tricuspid regurgitation, prosthetic tricuspid valve, or moderate to severe pulmonary hypertension; (5) Non-sinus rhythm (e.g., atrial flutter or fibrillation, paced rhythm, or complete heart block); (6) Poor-quality ultrasound images or inability to lie flat; (7) Patients with impaired circulation of the upper or lower limbs, such as those who have undergone radial artery harvest for coronary artery bypass grafting, suspected preoperative radial or dorsalis pedis artery occlusion, or previous aortic arch surgery; (8) Pregnant or breastfeeding women; (9) Participation in other interventional clinical trials within 1 month prior to screening; (10) Any other condition that, in the opinion of the investigator, makes the patient unsuitable for participation in this clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Radial artery time-velocity integral (rVTI);Resistance Index (RI);Minute Distance (MD); | — |
Secondary
| Measure | Time frame |
|---|---|
| Systemic Vascular Resistance Index (SVRI);Venous-to-arterial carbon dioxide partial pressure difference (Pv-aCO?);central venous blood oxygen saturation;lactic acid;Capillary Refill Time;Mottling Score; | — |
Countries
China
Contacts
Public ContactJian Chen
the First Affiliated Hospital of the University of Science and Technology of China (Anhui Provincial Hospital)
Outcome results
None listed