Trauma
Conditions
Interventions
Blank Group:None
Sponsors
Jinling Hosptial affiliated to Nanjing University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Age between 18-70 years old; 2. Trauma with hemorrhage: trauma patients with ongoing severe bleeding (systolic blood pressure 110 beats/min) or those considered at high risk of severe bleeding; 3. The patient or authorized representative has signed the informed consent form; 4. The subject is able to comply with the treatment protocol of this study.
Exclusion criteria
Exclusion criteria: 1. Uncertainty among senior physicians about whether to use antifibrinolytic drugs in patients with abdominal trauma complicated by bleeding; 2. Use of drugs that may affect intestinal function within 2 weeks (including but not limited to glutamine, intestinal probiotics, etc.); 3. Relative contraindications to tranexamic acid: (1) Known hypersensitivity to TXA; (2) Craniotomy within the past 28 days; (3) Use of anticoagulants or antiplatelet drugs within the past 2 weeks; (4) Active cerebrovascular bleeding; (5) Active thromboembolic disease (including but not limited to deep vein thrombosis, pulmonary embolism, cerebral thrombosis, ischemic stroke, or acute coronary syndrome); (6) Acute promyelocytic leukemia in remission induced by all-trans retinoic acid; (7) Use of combined hormonal contraceptives; 4. Pregnant or breastfeeding women; 5. Patients predicted by clinical experience to possibly die within 48 hours; 6. Patients with gastrointestinal organ injury; 7. Patients already enrolled in other clinical studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Indicators of intestinal barrier dysfunction: (intestinal permeability) Plasma D-lactate on DAY 3; | — |
Secondary
| Measure | Time frame |
|---|---|
| Assessment of Intestinal Barrier Permeability; | — |
Countries
China
Contacts
Public ContactDing Weiwei
Jinling Hosptial affiliated to Nanjing University
Outcome results
None listed