Postoperative cognitive dysfunction
Conditions
Interventions
Control group (Group C):Routine anesthesia management
Left stellate ganglion block group (L-SGB group):Ultrasound guided stellate ganglion block was performed 30 minutes before surgery, using 5ml of 1% lidocaine, and the block was performed on the left s
Right stellate ganglion block group (r-sgb group):Ultrasound guided stellate ganglion block was performed 30 minutes before surgery, using 5ml of 1% lidocaine, and the block was performed on the right
Sponsors
Chengdu Hospital of Integrated Traditional Chinese and Western Medicine (Chengdu First People's Hospital)
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients scheduled for non-cardiac surgery under general anesthesia; 2. Age >= 65 years old, gender not limited; 3.ASA grade II-III; 4. Estimated operation duration >= 2 hours or estimated anesthesia duration >= 3 hours; 5. Preoperative cognitive function is normal and the patient can cooperate to complete the cognitive function assessment; 6. The patient or their legal representative signs the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Cognitive dysfunction existed prior to the surgery; 2. Severe cardiac or pulmonary dysfunction or other major comorbidities; 3. Allergic to blocking drugs or having contraindications for nerve block; 4. Unable to cooperate with the study for any reason (such as visual impairment, hearing impairment, inability to communicate normally in Chinese, etc.) or the investigator deems it inappropriate to include in this study. Note.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of POCD within 7 days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| The levels of serum inflammatory factors (such as IL-6 and IL-10) were detected;Incidence of postoperative delirium;Postoperative adverse events;Incidence of nausea and vomiting within 24 hours;Postoperative 3-day recovery quality QoR-15 score; | — |
Countries
China
Contacts
Public ContactXiaomei Qiu
Chengdu Hospital of Integrated Traditional Chinese and Western Medicine (Chengdu First People's Hospital)
Outcome results
None listed