Gastric varices
Conditions
Interventions
EUS-guided precise ligation procedure:EUS-guided injection of tissue glue/spring coils into the GVs was performed. If moderate to severe EVs were present simultaneously, esophageal variceal ligation w
Endoscopic direct sclerotherapy:For obvious GVs, puncture needle injection of glyoxalate + tissue glue is performed. If moderate to severe EVs are present simultaneously, esophageal variceal ligation
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. 18 - 75 years old; 2. Cirrhosis (diagnosed through imaging, laboratory tests, clinical symptoms or liver biopsy); 3. Had acute rupture and bleeding of GVs (GOV1, GOV2 or IGV1) or previous rupture and bleeding (bleeding lesions observed under endoscopy originated from GVs or no other bleeding lesions were found except GVs); 4. Had occult GVs (i.e., not visible under traditional white light endoscopy, but visible under EUS); 5. Was willing to participate in this clinical study, complied with the study requirements and signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Suffering from advanced liver cancer or other malignant tumors with an expected lifespan of less than 3 months; 2. Complicated with severe diseases in other organs such as the heart, lungs, and kidneys.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The rates of all-cause rebleeding and bleeding-related mortality over a period of 6 weeks and 1 year; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence rate of operation-related adverse events;Hospitalization period;The rate of second endoscopic hemostasis;Success rate of endoscopic treatment;The incidence of other complications related to portal hypertension; | — |
Countries
China
Contacts
Public ContactWang Zhu
West China Hospital, Sichuan University
Outcome results
None listed