postoperative delirium
Conditions
Interventions
Permissive Hypercapnia + Phenylephrine Group:Intraoperative permissive hypercapnia maintained end-tidal carbon dioxide at 45 +/- 5
Continuous pumping of phenylephrine
Conventional Ventilation+ Phenylephrine Group:The end-expiratory carbon dioxide was maintained at 35 +/- 5
Continuous pumping of phenylephrine
Conventional Ventilation+ Ephedrine Group:Conventional ventilation (CV) with maintenance of end-tidal carbon dioxide (ETCO2) at 35+/-5 mmHg, combined with intermittent bolus injection of ephedrine
Sponsors
The Second Affiliated Hospital of Harbin Medical University
Eligibility
Sex/Gender
Male
Age
55 Years to 90 Years
Inclusion criteria
Inclusion criteria: (1) Age >= 55 years old (calculated in full chronological years); (2) American Society of Anesthesiologists (ASA) physical status classification ?-?; (3) No gender restriction.
Exclusion criteria
Exclusion criteria: (1) Inability to undergo neurocognitive function evaluation for any reason, including a history of neurological disorders (e.g., severe cognitive dysfunction, Parkinson's disease) and patients with communication impairments of any etiology. (2) Previous participation in any other clinical investigation within the preceding three months. (3) Any conditions judged inappropriate for study enrollment by the research team, including occurrence of serious adverse events (SAEs), severe cardiopulmonary insufficiency (NYHA Class?), preoperative regional cerebral oxygen saturation (rSO2) < 60%, sinus bradycardia, hypersensitivity to study medications, and major violations of study protocol by the patient.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| postoperative delirium;Regional cerebral oxygen saturation;Middle cerebral artery flow velocity: peak systolic velocity, diastolic velocity ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in hemodynamic parameters: MAP, HR; | — |
Countries
China
Contacts
Public ContactXi Hongjie
The Second Affiliated Hospital of Harbin Medical University
Outcome results
None listed