Infertility
Conditions
Interventions
Experimental group:The patients included were stratified by age into single-factor blocks and divided into three groups: 35-37 years old, 38-40 years old, and >=41 years old. Then, patients in each gr
Control group:The patients included were stratified by age into single-factor blocks and divided into three groups: 35-37 years old, 38-40 years old, and >=41 years old. Then, the patients in each gro
Sponsors
The Second Affiliated Hospital of Kunming Medical University
Eligibility
Sex/Gender
Female
Age
35 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 35 years old; 2. Patients with diminished ovarian reserve (DOR): Satisfy any 2 of the following criteria to meet the diagnosis of DOR: AMH = 10 IU/L or estrogen >= 80 pg/ml (The above standards are derived from the DOR diagnostic criteria formulated in the Chinese Expert Consensus on the Clinical Diagnosis and Treatment of Diminished Ovarian Reserve); 3. Patients who undergo superovulation with the high progesterone-based ovulation induction PPOS protocol.
Exclusion criteria
Exclusion criteria: 1. Age less than 35 years old; 2. Those with contraindications for assisted reproductive technology or pregnancy restrictions; 3. Individuals with chromosomal abnormalities in either partner, except for advanced age, have obvious causes that may lead to DOR, such as history of ovarian cystectomy, history of unilateral ovary resection, or history of fallopian tube resection, etc.; 4. Individuals with uterine anatomical abnormalities; 5. Have immune diseases (such as antiphospholipid antibody syndrome, dryness syndrome, systemic lupus erythematosus, etc.); 6. Have systemic diseases that are poorly controlled (such as thyroid dysfunction, hypertension, diabetes, coronary heart disease, renal insufficiency, etc.); 7. Male factor infertility; 8. Individuals with allergic or contraindicated conditions to exogenous growth hormone.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of antral follicles;Number of follicles on HCG day;Number of retrieved oocytes;Mitochondrial membrane potential of cumulus granulosa cells;Level of ROS in follicular fluid;Number of fertilizations;Number of superior embryos;Fertilization rate;Superior embryo rate; | — |
Countries
China
Contacts
Public ContactJiang Fangjie
The Second Affiliated Hospital of Kunming Medical University
Outcome results
None listed