Spinal Surgery
Conditions
Interventions
remimazolam group:Continuous intravenous pumping of remifentanil at 0.1-0.2 µg/kg/min and remimazolam at 1-2 mg/kg/h was performed intraoperatively
propofol group:Continuous intravenous pumping of remifentanil at 0.1-0.2 µg/kg/min and propofol at 5-8 mg/kg/h was performed intraoperatively
Sponsors
Beijing Tiantan Hospital, Capital Medical University, Beijing, China
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 65 years; 2. Body mass index (BMI) ranging from 18.5 to 23.9 kg/m²; 3. American Society of Anesthesiologists (ASA) physical status classification ? to ?; 4. Scheduled for spinal column and spinal cord surgery; 5. Informed consent obtained.
Exclusion criteria
Exclusion criteria: 1. Known or suspected severe cardiac, pulmonary, hepatic or renal dysfunction (1) Severe cardiac dysfunction: a. Unstable coronary artery syndrome b. Congestive heart failure: left ventricular ejection fraction (LVEF) = 1.5 b. Serum total bilirubin (TBil) >= 171 µmol/L (4) Severe renal dysfunction: a. Endogenous creatinine clearance rate (Ccr) < 30 ml/min b. Glomerular filtration rate (GFR) < 30 ml/min•1.73 m² 2. Idiopathic epilepsy or long-term administration of antiepileptic drugs 3. Coagulopathy, other psychiatric or neurological diseases 4. History of chronic alcohol consumption or long-term use of sedative drugs 5. Hypersensitivity to remimazolam or propofol 6. Patients unable to cooperate with monitoring
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Motor Evoked Potentials Amplitude; | — |
Secondary
| Measure | Time frame |
|---|---|
| Somatosensory Evoked Potentials Amplitude;Motor Evoked Potential Latency;Somatosensory Evoked Potentials Latency;Japanese Orthopaedic Association score; | — |
Countries
China
Contacts
Public ContactRanquan Han
Beijing Tiantan Hospital Affiliated to Capital Medical University
Outcome results
None listed