Non-alcoholic fatty liver disease
Conditions
Interventions
High-Intensity Interval Training Group:The exercise protocol of HIIT is designed with reference to the FITT Principle proposed by the American College of Sports Medicine (ACSM). It involves three trai
this phase consists of three sets of 4-minute cycling bouts, with 2 minutes of active recovery at 50% HRR between sets, and the total duration of this phase is 15–20 minutes. The third is the cool-dow
Moderate-Intensity Continuous Training Group:The weekly exercise volume of MICT is set at 750 MET-min/wk. The exercise protocol is designed with reference to the FITT Principle proposed by the America
Sponsors
Beijing Sport University
Eligibility
Sex/Gender
All
Age
40 Years to 69 Years
Inclusion criteria
Inclusion criteria: 1. Aged 40–69 years; 2. Sedentary lifestyle, defined as less than 90 minutes of physical activity per week; 3. Obesity, defined as a body mass index (BMI) >= 30 kg/m²; 4. MRI-proton density fat fraction (MRI-PDFF) >= 5%.
Exclusion criteria
Exclusion criteria: 1. Presence of unstable cardiovascular disease symptoms; 2. Excessive alcohol consumption (men > 30 g/day, women > 20 g/day, or AUDIT-C score >= 4); 3. Diagnosis of type 2 diabetes mellitus; 4. Presence of other liver diseases (e.g., viral hepatitis); 5. history of cancer; 6. Recent significant weight fluctuations; 7. Inability or unwillingness to provide written informed consent; 8. Any other condition deemed by the investigators to make participation in the study unsuitable.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intrahepatic triglyceride;Thigh Skeletal Muscle Volume; | — |
Secondary
| Measure | Time frame |
|---|---|
| Fibroblast Growth Factor 21;Myostatin;Irisin;Fasting Blood Glucose ;Fasting Insulin;Homeostatic Model Assessment of Insulin Resistance;Quantitative Insulin Sensitivity Check Index;Weight;Waist Circumference;Hip Circumference;Waist-to-Hip Ratio ;Body Mass Index;Alanine Aminotransferase;Aspartate Aminotransferase;Total Cholesterol;High-Density Lipoprotein Cholesterol;Low-Density Lipoprotein Cholesterol;Triglycerides; | — |
Countries
China
Contacts
Public ContactXueying He
China Institute of Sport and Health Science
Outcome results
None listed