Spinal degenerative disorders
Conditions
Interventions
Desflurane group:Induction and maintenance of anesthesia with desflurane
Remimazolam group:Induction and maintenance of anesthesia with remimazolam
Sponsors
Guizhou Provincial People's Hospital, Guiyang City, Guizhou Province
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: Inclusion criteria: 1. Diagnosed with frailty after assessment using the frailty scale; 2. Undergoing prone position spinal surgery under general anesthesia, with an expected operation duration of 2-5 hours; 3. ASA grade I-III; 4. BMI 18-30 kg/m^2; 5. Age >= 65 years old; 6. Agree to participate in this study, understand the surgical plan and anesthesia risks, and voluntarily sign the informed consent form.
Exclusion criteria
Exclusion criteria: Exclusion criteria: 1. Allergic to the trial drug, having had adverse reactions before, or having other conditions that cannot tolerate general anesthesia; 2. With a history of mental disorders and psychological disorders, having recently used antipsychotic drugs and antidepressants, or requiring long-term use of hypnotics and sedatives; 3. Refusing to be enrolled or having other situations that cannot cooperate with the trial; 4. Emergency surgery patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean arterial pressure; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate;Systolic blood pressure;diastolic blood pressure;Oxygen saturation;Intraoperative dosage of vasoactive drugs (norepinephrine);Intraoperative opioid dosage;Operation time;Anesthesia duration;Anesthesia depth BIS;Occurrence of vascular adverse events in the surgical center;Postoperative recovery time;Time for removing tracheal tube;Occurrence of adverse events in PACU;Postoperative recovery quality;Length of hospital stay; | — |
Countries
China
Contacts
Public ContactMing chen
Guizhou Provincial People's Hospital, Guiyang City, Guizhou Province
Outcome results
None listed