Alzheimers disease
Conditions
Interventions
Normal brain aging group: 1.Walking Task (WT):The subject walked back and forth once in the gait testing area at a natural gait, without cognitive tasks
2.Walking while Naming Animals (WMT):The subject was required to name animals aloud while walking, attempting to list as many animal names as possible
3.Walking while Calculating Arithmetic Tasks (WCT) :The subject was required to perform serial subtraction, counting aloud backwards from 100 while walking.
Normal Structure Group: 1.Walking Task (WT):The subject walked back and forth once in the gait testing area at a natural gait, without cognitive tasks
AD group: 1.Walking Task (WT):The subject walked back and forth once in the gait testing area at a natural gait, without cognitive tasks
Sponsors
Zhejiang Rehabilitation Medical Center
Eligibility
Sex/Gender
All
Age
40 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. AD Group (1) Aged >= 40 years and = 40 years and = 40 years and= 26 points, indicating that the current cognitive function is within the normal range;(3)Imaging examinations (e.g., MRI) suggesting the absence of brain aging;(4) A Hachinski Ischemia Scale (HIS) score<= 4 points to exclude vascular dementia;(5) A Hamilton Depression Scale (HAMD) score < 20 points to exclude senile depression;(6) No functional impairments such as severe osteoarticular diseases, and having the ability to walk independently;(7) Basically capable of undergoing visual and auditory tests;(8) Those who understand the basic relevant information of this study, agree to participate in the observation of this study, and sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Severe dementia as assessed by the Clinical Dementia Rating (CDR), with a CDR score of 3.0; (2) A Hachinski Ischemia Scale (HIS) score > 4 points; (3) A Hamilton Depression Scale (HAMD) score >=20 points; (4) Dementia caused by other systemic diseases or neurological disorders, such as dementia following central nervous system infection, post-traumatic dementia, and Parkinson's disease dementia; (5) Suffering from acute diseases, upper limb extrapyramidal rigidity, neurological or psychiatric diseases (excluding cognitive impairment), severe orthopedic diseases (e.g., severe osteoarthritis) involving the lumbar spine, pelvis, or lower limbs, or being unable to walk independently; (6) A history of interference with cognitive function assessment, such as a past history of psychotropic substance abuse, drug use within the past 5 years, or alcoholism; (7) Aged under 40 years or over 90 years; (8) Currently participating in other clinical trials that may affect the evaluation of the results of this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gait Parameters; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical Functional Assessment;Imaging Parameters;Safety Parameters; | — |
Countries
China
Contacts
Public ContactZhang Shuijing
Zhejiang Rehabilitation Medical Center
Outcome results
None listed