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A retrospective analysis of ROR1 expression and previous antitumor efficacy and prognosis in patients with DLBCL

A retrospective study of the correlation between receptor tyrosine kinase-like orphan receptor 1 (ROR1) expression and previous antitumor efficacy and prognosis in patients with diffuse large B-cell lymphoma

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600117598
Enrollment
Unknown
Registered
2026-01-27
Start date
2025-01-22
Completion date
Unknown
Last updated
2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

DLBCL

Interventions

Trial group:NA

Sponsors

Cancer Hospital Chinese Academy of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Age >= 18 years old, male or female; 2. Patients with histologically or cytologically confirmed DLBCL (including DLBCL NOS, CLL-transformed DLBCL, indolent lymphoma-transformed DLBCL, and HGBL with double/triple blows). 3. There are sufficient tumor FFPE samples or retained tissue white films, and the subsequent routine diagnosis and treatment of patients should not be affected after the samples are removed or the retained white films are used; 4. The sample should be biopsy tissue from the time of initial diagnosis of DLBCL. If the patient re-undergoes biopsy when the disease recurs or progresses, it can also be sent for testing as appropriate; Each case should have at least the biopsy tissue from the time of initial diagnosis; 5. Have relatively complete diagnosis and treatment information of our hospital (including baseline characteristics, treatment plan, efficacy evaluation and other data).

Exclusion criteria

Exclusion criteria: 1. There are no patients with biopsy tissue samples or blank films at the time of initial diagnosis of DLBCL; 2. Patients with incomplete diagnosis and treatment information records in the HIS system, which affects the analysis of clinical information; 3. Diseases other than DLBCL diagnosis; 4. Patients who are considered by other investigators to be unsuitable to participate in this study.

Design outcomes

Primary

MeasureTime frame
ROR1 Positivity rate;ROR1 H-score;

Countries

China

Contacts

Public ContactYuankai Shi

Cancer Hospital Chinese Academy of Medical Sciences

syuankai@cicams.ac.cn+86 10 87788787

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 7, 2026