slow-flow vascular malformation
Conditions
Interventions
Combination Therapy Group:Sirolimus
Standard Intervention Group:Interventional therapy
Sponsors
Jinan Children's Hospital
Eligibility
Sex/Gender
All
Age
No minimum to 18 Years
Inclusion criteria
Inclusion criteria: 1.Age 0 to 18 years, no gender restrictions; 2.Confirmed diagnosis of low-flow vascular malformation; 3.No systemic treatment for this lesion within the past six months; 4.Planned to undergo two standardized interventional procedures at this center within six months, with efficacy assessed as “ineffective” (lesion reduction <25%); 5.Guardian signed informed consent form with good compliance.
Exclusion criteria
Exclusion criteria: 1.Patients with a confirmed diagnosis of other vascular malformations such as arteriovenous malformations or Parkes-Weber syndrome; 2.Allergic reactions to interventional therapy-related medications (e.g., piperacillin, iodinated contrast agents); 3.Received other treatments within one month prior to enrollment; 4.Concurrent severe cardiac, pulmonary, hepatic, renal, or hematologic disorders rendering treatment intolerable; 5.Currently receiving immunosuppressive therapy or other medications that may interfere with efficacy assessment; 6.Guardians anticipated to have difficulty completing follow-up or demonstrate poor compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical response rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Early efficacy; | — |
Countries
China
Contacts
Public ContactLiang Wang
Jinan Children's Hospital
Outcome results
None listed