postoperative pain and delirium
Conditions
Interventions
Hydromorphone group:hydromorphone for patient-controlled analgesia
Nalbuphine group:nalbuphine for patient-controlled analgesia
Hydromorphone+nalbuphine group:nalbuphine combined with nalbuphine for patient-controlled analgesia
Sufentanil group:sufentanil for patient-controlled analgesia
Sponsors
Binzhou Medical University Affiliated Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing laparoscopic surgery are aged 18 to 65 years; 2. ASA I-III level; 3. BMI 18-35 kg/m^2;
Exclusion criteria
Exclusion criteria: 1. Illiteracy; 2. Patients with central nervous system disease or mental illness or have recently taken sedatives, antidepressants, a history of alcoholism, a history of drug dependence or long-term treatment with any sleep medication in the past 6 months, patients with a history of dementia and delirium; 3. Inability to communicate effectively; 4. Individuals with severe impairment of heart, lung, liver, kidney, or other organ functions; 5. Patients with non-surgical pain-related diseases, such as herpes zoster; 6. History of allergy to opioid drugs like hydromorphone and nalbuphine; 7. Patients with acute asthma or other severe respiratory diseases; 8. Postoperative transfer to the ICU; 9. Pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative pain assessment;The occurrence rate of delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| The number of presses about patient-controlled analgesia pump ;Plasma melatonin level;Cortisol concentration;Neuron-specific enolase; | — |
Countries
China
Contacts
Public ContactChao Sun
Binzhou Medical University Affiliated Hospital
Outcome results
None listed