Childhood Nephrotic Syndrome
Conditions
Interventions
Observation Group:NA
Sponsors
Children's Hospital of Fudan University
Eligibility
Sex/Gender
All
Age
No minimum to 18 Years
Inclusion criteria
Inclusion criteria: 1. Age Range: Participants must be between 0 and 18 years of age (inclusive), with no restrictions on gender. 2. Diagnostic Criteria: Must exhibit nephrotic-range proteinuria, defined as either a urine protein/creatinine ratio >= 2.0 mg/mg, a 24-hour urinary protein excretion >= 50 mg/kg, or a urine protein dipstick result of >= 3+. This must be accompanied by at least one of the following: hypoalbuminemia (serum albumin < 30 g/L) or pitting edema (in cases where serum albumin results are unavailable). 3. First Diagnosis or Ongoing Treatment: Includes newly diagnosed cases, as well as cases admitted due to relapse or for treatment (including cases transferred from other institutions or previously diagnosed at partner institutions). All these cases should be enrolled to construct a comprehensive disease spectrum. 4. Informed Consent: Written informed consent must be obtained from the parent or legal guardian. 5. Good Compliance: Cases where the patient is expected to complete the follow-up plan and cooperate with data collection.
Exclusion criteria
Exclusion criteria: 1. Secondary Nephrotic Syndrome: Cases with a clear etiology of systemic diseases, such as systemic lupus erythematosus, Henoch-Schönlein purpura, diabetic nephropathy, or infection-associated glomerulonephritis. 2. Ineligible Cases: Patients who are unable to comply with follow-up requirements or for whom informed consent could not be obtained.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to First Relapse; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of relapses per patient during 24- week follow-up after completion of steroid therapy; | — |
Countries
China
Contacts
Public ContactXu Hong
Children's Hospital of Fudan University
Outcome results
None listed