Body Weight in Chinese Population
Conditions
Interventions
Trial group:Take one capsule containing heat-inactivated Akkermansia muciniphila MucT orally once daily with dinner for 90 consecutive days.
Sponsors
The international peace maternity and child health hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Before the trial, sign the informed consent form and have a thorough understanding of the trial content, process and possible adverse reactions. 2.Age: 18-70 years old (including 18 and 70); 3.Body Mass Index (BMI) between 25-30 (including 25 and 30); 4.log10 AKK ng/g fecal DNA<0;
Exclusion criteria
Exclusion criteria: 1. Women who are planning to conceive, are pregnant, or are breastfeeding; 2. Have undergone any type of weight loss surgery; 3. Have used any medication within the last 6 months that may control blood sugar and insulin (such as metformin) or plan to use medication during the study period; 4. Using any weight-loss medication within the past three months or planning to use medication during the study period; 5. Have participated in, are currently participating in, or plan to participate in other clinical trials within the past three months during the research period; 6. In the past three months, the consumption of dietary supplements included omega-3 fatty acids, probiotics, prebiotics, phytosterols/sterols, or those planned to be consumed during the study period; 7. Within the past three months, have received antibiotic treatment or are planning to use medication during the study period; 8. Weight fluctuation of >=5kg in the past 3 months; 9. Suffering from malignant tumors; 10. There are cardiovascular, immune, respiratory, gastrointestinal, biliary, kidney and urinary systems, nervous and musculoskeletal systems, mental disorders, thyroid diseases, or there are severe endocrine, liver, and infectious diseases and complications; 11. Creatinine >=2^1 times the upper limit of the standard; Aspartate aminotransferase (AST) or Alanine aminotransferase (ALT) >=3^1 times the upper limit of the standard; 12. Alcohol consumption (>2 cups per day); 13. Smoking more than 10 cigarettes per day; 14. Those who are allergic to probiotic products, tea products, or have a history of drug allergy or allergic diseases; 15. Any condition that, in the judgment of the researcher, hinders participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Weight; | — |
Secondary
| Measure | Time frame |
|---|---|
| Other indicators (including fasting glucose, insulin, HbA1c, HOMA-Index, total cholesterol, low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), triglycerides, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), total bilirubin (Tbil), high-sensitivity C-reactive protein (hsCRP), waist circumference, BMI, blood pressure, Depression-Anxiety-Stress Scale (DASS-21), Gastrointestinal Symptom; | — |
Countries
China
Contacts
Public ContactSun Wenguang
The international peace maternity and child health hospital
Outcome results
None listed