Heart Failure with Reduced Ejection Fraction
Conditions
Interventions
LIPUS Active Treatment Group:In addition to conventional medication and exercise intervention, subjects in this group received active LIPUS treatment after each exercise session. The treatment regimen
LIPUS Sham Treatment Group:In addition to conventional medication and exercise intervention, subjects in this group received sham LIPUS treatment after each exercise session. The treatment regimen was
Sponsors
Peking Union Medical College Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Age 18-75 years; (2) Left ventricular ejection fraction (LVEF) measured by Simpson's biplane method on echocardiography is 35%-50%; (3) Meets the diagnostic criteria for chronic stable heart failure; (4) Patients are fully informed and have signed the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Acute heart failure (hemodynamically unstable); (2) Acute coronary syndrome (within 2 days of onset); (3) Resting systolic blood pressure >180 mmHg or diastolic blood pressure >110 mmHg; (4) New-onset or uncontrolled severe arrhythmia (e.g., malignant ventricular arrhythmia, new-onset atrial fibrillation/flutter, frequent ventricular premature contractions (increase >5 beats/min during exercise or recovery)); (5) High-grade (second-degree type II) or third-degree atrioventricular block (without pacemaker implantation); (6) Dynamic ST-segment depression >0.1 mV in adjacent leads on electrocardiogram or severe myocardial ischemic symptoms during low-power exercise (13.9 mmol/L or ketosis); (17) After pacemaker or ICD implantation (contraindication for LIPUS); (18) Severe motor dysfunction preventing completion of the trial protocol; (19) Progressive worsening of dyspnea at rest or significant decline in exercise tolerance within the last 3–5 days; (20) Refusal to participate in the study or sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Left ventricular ejection fraction;Six-Minute Walk Distance; | — |
Secondary
| Measure | Time frame |
|---|---|
| Peak oxygen uptake (VO?peak);Heart rate variability (HRV);Quality of life (QoL);Mental and psychological status; | — |
Countries
China
Contacts
Public ContactRongjing Ding
Peking Union Medical College Hospital
Outcome results
None listed