Bilateral Acute Iris Transillumination, BAIT
Conditions
Interventions
BAIT group:NA
Control group:NA
Sponsors
Beijing Tongren Hospital
Eligibility
Sex/Gender
All
Age
30 Years to 40 Years
Inclusion criteria
Inclusion criteria: Group 1: Control Group 1. Demographics: Age 30–40 years, any gender, Han Chinese ethnicity. 2. Medical History: Previous history of respiratory tract infection. 3. Medication History: Previous use of anti-infective medications, with an interval of at least 2 weeks between medication administration and the current assessment. 4. Ocular Symptoms: No history of glaucoma-like symptoms after medication use, such as ocular pain, redness, blurred vision, or elevated intraocular pressure (IOP). 5. Slit-lamp Examination: No pigmented keratic precipitates (KP) on the cornea. No iris depigmentation or iris transillumination defects. Absence of pigment granules or inflammatory cells in the aqueous humor. Group 2: BAIT Group 1. Infection History: Documented history of respiratory tract infection. 2. Medication History: Documented use of anti-infective medications. 3. Iris & Pupil Signs: Massive irregular iris depigmentation and iris transillumination. Photophobia. Relative reduction in pupillary sphincter tone accompanied by mydriasis (dilated pupils). 4. Clinical Symptoms: Significant elevation of intraocular pressure (IOP), ocular pain, conjunctival/ciliary congestion, blurred vision, etc.
Exclusion criteria
Exclusion criteria: Control Group Exclusion Criteria: 1. Concurrent Ocular Diseases: Presence of other severe eye diseases that affect visual function, such as glaucoma, corneal inflammation (keratitis) or opacity, uveitis, significant lens opacity (cataract), proliferative diabetic retinopathy (PDR), arteritic anterior ischemic optic neuropathy (AAION), macular hole, retinal detachment, or retinitis pigmentosa. 2. Systemic Diseases: History of systemic conditions, including hemorrhagic diseases, patients in the acute phase of cerebral hemorrhage, severe cardiac disease, severe arrhythmia, heart failure, or severe hepatic or renal dysfunction. 3. Allergic Constitution: Known history of drug or food allergies. 4. Special Populations: Women who are pregnant, planning a pregnancy, or breastfeeding. 5. Investigator Discretion: Patients deemed unsuitable for participation in the study by the researcher. BAIT Group Exclusion Criteria: 1. Primary Glaucoma: Including primary open-angle or angle-closure glaucoma. 2. High Myopia with Pigmentary Glaucoma: Specifically excluding cases where pigment dispersion is secondary to high myopia. 3. Other Secondary Glaucomas: Such as steroid-induced glaucoma, traumatic glaucoma, or other forms of secondary glaucoma.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HLA (Human Leukocyte Antigen) genotyping; | — |
Countries
China
Contacts
Public ContactQiao Chunyan
Beijing Tongren Hospital
Outcome results
None listed