Infertility in patients with Polycystic Ovary Syndrome
Conditions
Interventions
Control Group:Placebo+Letrozole
Combination Treatment Group:Placebo+Jinfeng Pill+Letrozole
Pre-treatment Group:Jinfeng Pill+Letrozole
Sponsors
Shanghai First Maternity and Infant Hospital
Eligibility
Sex/Gender
Female
Age
20 Years to 35 Years
Inclusion criteria
Inclusion criteria: 1. Women aged 20-35; 2. Meet the diagnostic criteria for PCOS-related infertility; 3. Have a desire to conceive; 4. Have a partner with normal semen analysis; 5. Willing to sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Individuals who are infertile due to congenital physiological defects or malformations; 2. Individuals who are infertile due to genetic factors; 3. Individuals who are infertile due to tubal factors, endometriosis, adenomyosis, uterine fibroids, uterine developmental abnormalities, combined ovarian tumors, or non-physiological cysts confirmed by examination; 4. Abnormal reproductive function in the spouse; 5. Patients with severe primary diseases of the cardiovascular, liver, kidney, or hematopoietic systems, or psychiatric disorders; 6. Individuals who have used hormones or other related or antagonistic drugs within the past 3 months, making it difficult to assess drug efficacy; 7. Patients currently participating in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical Pregnancy Rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Age;Height;Weight;Body Mass Index;Duration of Infertility;Follicle-Stimulating Hormone;Luteinizing Hormone;Estradiol;Progesterone;Total Testosterone;Anti-Müllerian Hormone;Fasting Plasma Glucose;Fasting Insulin;Homeostatic Model Assessment for Insulin Resistance;Live Birth Rate;Ovulation Rate;Spontaneous Abortion Rate;Ectopic Pregnancy Rate;Multiple Pregnancy Rate;C-Reactive Protein;Interleukin-6;Interleukin-18;D-dimer;Glycated Hemoglobin ;Triglycerides;Total Cholesterol;Low-Density Lipoprotein Cholesterol;High-Density Lipoprotein Cholesterol; | — |
Countries
China
Contacts
Public ContactQian Zhou
Shanghai First Maternity and Infant Hospital
Outcome results
None listed