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Research on the mechanism and targeted intervention strategy of ZBP1 lactation modification in chondrocyte aging and osteoarthritis

Research on the mechanism and targeted intervention strategy of ZBP1 lactation modification in chondrocyte aging and osteoarthritis

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600117546
Enrollment
Unknown
Registered
2026-01-26
Start date
2026-02-01
Completion date
Unknown
Last updated
2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

knee osteoarthritis

Interventions

Knee osteoarthritis (K-L Grade IV) group:none

Sponsors

Zhejiang Provincial People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Patients undergoing knee replacement; 2. Age=18 years; 3. Signed informed consent.

Exclusion criteria

Exclusion criteria: 1.Combined with other joint diseases, infections, tumors, immune system diseases, etc.

Design outcomes

Primary

MeasureTime frame
The content of lactic acid in cartilage samples;Expression levels of molecules related to lactate metabolism;Cellular senescence marker;Degree of cartilage degeneration;—

Countries

China

Contacts

Public ContactHong Zheping

Zhejiang Provincial People's Hospital

frankhong671101@163.com+86 571 8589 3359

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 7, 2026