Breast cancer patients undergoing breast reconstruction after mastectomy
Conditions
Interventions
study group:Take pirfenidone orally
Sponsors
Zhejiang Cancer Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Age 18~70 years. 2.ECOG PS score < 2. 3.Breast cancer patients who have undergone total mastectomy and postoperative reconstruction. 4.Planned to receive adjuvant radiotherapy. 5.No history of other malignancies (except basal cell carcinoma of the skin). 6.Informed consent form signed before the study began.
Exclusion criteria
Exclusion criteria: 1.Clinically or radiologically confirmed presence of metastatic disease. 2.History of chest radiation therapy. 3.Combining scleroderma, active lupus erythematosus, and other autoimmune diseases. 4.Pregnant or lactating patients. 5.Combined severe cardiac, pulmonary, hepatic, renal, hematopoietic system, neurological disorders or psychiatric diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of >= Baker Grade ? capsular contracture; | — |
Secondary
| Measure | Time frame |
|---|---|
| Local recurrence rate;Prosthesis loss rate.;Local regional recurrence rate;Beauty effects.;Disease free survival;Overall survival; | — |
Countries
China
Contacts
Public ContactHonglian Ma
Zhejiang Cancer Hospital
Outcome results
None listed