Postoperation Nausea and Vomiting
Conditions
Interventions
The Real stimulation group (The intervention group):Using the gammacore (ElectroCore, LLC) instrument, a single 120-second vagus nerve stimulation was performed on the cervical branch of the internal
The sham stimulation group (The control group):Using the same instrument, after placing it in the correct position, start the stimulation. Use a stimulus intensity of less than 3 to stimulate the righ
Sponsors
Beijing Shijitan Hospital, Capital Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients scheduled for gynecological laparoscopic surgery under general anesthesia; 2. Age 18-65; 3. American Society of Anesthesiologists (ASA) class I–III; 4. High risk for postoperative nausea and vomiting, score 3-4; 5. Voluntarily participate in the study and sign the informed consent form. Exclusion criteria.
Exclusion criteria
Exclusion criteria: 1. Presence of nVNS contraindications (having implanted medical devices or metal devices in or near the neck) or injury at the stimulation site; 2. Preoperative sinus bradycardia (100 bpm); 3. Long-term use of long-acting antiemetics, emetics, opioids, or glucocorticoids; 4. Pregnancy or breastfeeding; 5. Presence of other conditions that may cause nausea or vomiting, such as hepatitis or gastric ulcers, or occurrence within the past week; 6. Patients whose nausea and vomiting symptoms have not resolved; 7. History of prior vagus nerve surgery; 8. Uncontrolled hypertension or hypotension; 9. Severe cardiovascular, hepatic, or renal disease, or mental or neurological disorders preventing participation in the study; 10. Hearing or speech impairments; 11. Refusal to cooperate with the experiment; 12. Preoperative gastric emptying disorders (persistent postprandial fullness and nausea due to poor long-term blood sugar control; sleeve gastrectomy; multiple sclerosis; scleroderma; taking medications such as semaglutide that delay gastric emptying).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of postoperative nausea and vomiting within 24 hours in both groups; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence rates of postoperative nausea and postoperative vomiting (dry vomiting) within 0-6 hours and 6-24 hours after the operation;The number of patients who experienced varying degrees of postoperative nausea, postoperative vomiting, and postoperative retching within 24 hours after the operation;The number of patients requiring emergency antiemetic drugs within 24 hours after surgery and the amount of rescue medication used;The number of patients requiring emergency analgesics within 24 hours after surgery and the details of their medication usage;Postoperative 24-hour Numerical Rating Scale (NRS) pain score;The time of the first postoperative expulsion of gas and defecation for the two groups;The heart rate variability indicators before and after the first stimulation and the heart rate variability indicators before and after the second stimulation;The levels of serum IL-6, IL-1ß, TNF-a and IL-10 in the venous blood collected in the morning before the operation and on the first day after the operation;The Bang blindness index (BBI) of the two groups; | — |
Countries
China
Contacts
Public ContactMiao Huihui
Beijing Shijitan Hospital, Capital Medical University
Outcome results
None listed