The optimized management of acute postoperative pain following bariatric surgery
Conditions
Interventions
Esmolol Group :A loading dose of esmolol (0.5mg/kg) was administered intravenously. Intravenous pump (0.05mg/ (kg·min))
Normal Saline Group:Intravenous injection of 0.9% Normal Saline
Sponsors
Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Zhejiang, Hangzhou, China
Eligibility
Sex/Gender
All
Age
18 Years to 59 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18 to 59 years old (inclusive of the boundary values). 2.Patients classified as ASA Physical Status Class I–III. 3.Patients scheduled to undergo bariatric surgery for gastric volume reduction. 4.Voluntarily participate in this study and sign the informed consent form. If the subject is unable to read the informed consent form (e.g., illiterate subjects), the informed consent process shall be witnessed by a third party, who will then sign the informed consent form along with the subject.
Exclusion criteria
Exclusion criteria: 1.Patients with a history of drug abuse or opioid dependence. 2.Bronchial asthma or a history of bronchial asthma. 3.Severe chronic obstructive pulmonary disease (COPD). 4.Severe sinus bradycardia. 5.Second- to third-degree atrioventricular block. 6.Refractory cardiac insufficiency. 7.Cardiogenic shock. 8.Patients hypersensitive to esmolol. 9.Vulnerable groups excluding illiterate people, including critically ill patients, individuals with cognitive impairment, patients with mental disorders, pregnant women, etc. 10.Other circumstances where the investigator deems the subject unfit to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative opioid consumption within 72 hours; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative pain score;Quality of postoperative recovery;Adverse reaction; | — |
Countries
China
Contacts
Public ContactZhao Hongyan
Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Zhejiang, Hangzhou, China
Outcome results
None listed