postoperative analgesia in patients with lower limb fractures
Conditions
Interventions
M group:At the end of the operation (after the last suture was completed), 1mg of Taglidine fumarate injection was intravenously administered, and a patient-controlled intravenous analgesia pump for t
FL group:At the end of the operation (after the last suture was completed), 0.5mg of Taglidine fumarate injection was intravenously administered, and a patient-controlled intravenous analgesia pump fo
FH group:At the end of the operation (after the last suture was completed), 1mg of Taglidine fumarate injection was intravenously administered, and a patient-controlled intravenous analgesia pump for
Sponsors
Tianjin First Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1Age between 18-80 years old, male and female; 2Subjects under elective general anaesthesia for lower limb fracture surgery, the expected duration of the operation 1h-4h, and the expected need for more than 48h of postoperative self-control intravenous analgesia pump treatment (moderate and severe pain); 3General anaesthesia for tracheal intubation, ASA anaesthesia classification ? - ?; 418kg/m^2<=body mass index (BMI) <=30kg/m^2; 5Subjects fully understand the purpose of this trial, the process and risks, and voluntarily signed an informed consent to participate in the clinical trial. = 30kg/m^2; 5. Subjects fully understood the purpose, content, process and risk of this trial, and voluntarily participated in the clinical trial and signed an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients who refuse to participate in the trial; 2. Patients who are allergic to the trial medication or who have had serious adverse reactions in the past; 3. Patients who have been taking sedative or analgesic medication for a long period of time prior to the procedure; 4. Those who are at a high risk of bronchial asthma or respiratory depression; 5. Patients who are unable to communicate due to hearing, vision, or speech disorders; 6. Patients who are combined with severe hepatic dysfunction (Child-Pugh class C); 7. Patients who are combined with severe renal dysfunction (requiring renal replacement therapy); 8. Patients with traumatic shock. Patients with severe renal dysfunction (requiring renal replacement therapy); 8. Patients with traumatic shock.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Numerical Rating Scale(NRS) scores at Rest and during Activity ;Percentage of subjects using rescue analgesics; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of moderate to severe nausea and vomiting within 48 hours after the operation;The time when analgesics are needed for the first time after the operation and the dosage of postoperative remedial opioids;The levels of white blood cells and C-reactive protein in the first postoperative blood routine test; | — |
Countries
China
Contacts
Public ContactYu Wenli
Tianjin First Central Hospital
Outcome results
None listed