Postherpetic neuralgia
Conditions
Interventions
experimental group:Sequential stimulation of M1 + DLPFC
control group:M1 + vertex sequential stimulation
Sponsors
The FIrst Affiliated Hospital, College of Medicine, Zhejiang University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Meets the IASP diagnostic criteria for postherpetic neuralgia, with a disease duration of >=3 months; 2.18 to 75 years old; 3.The average NRS score for daily pain over the past 1 week was greater than 3 points; 4.It can be used in conjunction with clinical assessment, rTMS treatment and electroencephalogram monitoring. 5.Be able to understand the nature and purpose of the research, be willing to participate and be able to comply with the requirements of the research protocol, including undergoing von Frey filament stimulation and brain electrical monitoring;
Exclusion criteria
Exclusion criteria: 1. TMS contraindications (e.g. presence of magnetic objects, implants, metallic fragments or foreign bodies within the body; unhealed acute wounds or surgical incisions; claustrophobia; presence of any type of vascular stents, clips or prior surgical interventions; inability to lie supine due to medical conditions); 2. Individuals with psychiatric disorders, aphasia, or cognitive impairment (HAMD 17-item score >24, HAMA 14-item score >29, MMSE <= 24); 3. Presence of severe cardiopulmonary dysfunction, extreme debility, or inability to sit upright and cooperate with treatment; 4. Other conditions likely to interfere with study outcomes, such as epilepsy or myocardial infarction; 5. Pregnant or breastfeeding women; 6. Currently participating in other clinical trials or receiving treatment with other investigational medicinal products.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in pain following stimulation therapy (NRS score); | — |
Secondary
| Measure | Time frame |
|---|---|
| Indicators of Neural Plasticity in the Patient's Brain;SF-MPQ;von Frey thresholds;PGIC; | — |
Countries
China
Contacts
Public ContactFeng Zhiying
The FIrst Affiliated Hospital, College of Medicine, Zhejiang University
Outcome results
None listed