Laparoscopic Total Hysterectomy
Conditions
Interventions
N group:Within 15 minutes after the end of surgery, bilateral transversus abdominis plane (TAP) block was performed with a mixture of 5 mg oxycodone and 0.375% ropivacaine (total volume: 40 ml), with
P group:A patient-controlled analgesia infusion (PCAI) system was connected immediately after surgery, containing 0.5 mg/kg oxycodone, 8 mg ondansetron, and normal saline (total volume: 100 ml). The i
Sponsors
The Second People's Hospital of Yibin City
Eligibility
Sex/Gender
Female
Age
35 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.All participants signed the informed consent form. 2.Aged 35 to 75 years old. 3.American Society of Anesthesiologists (ASA) physical status classification ? to ?. 4.Undergoing elective laparoscopic surgery with the operative duration ranging from 1 to 4 hours. 5.Preoperative Barthel Index score = 95 points.
Exclusion criteria
Exclusion criteria: 1.Patients with mental or psychological disorders. 2.Patients with a history of chronic alcoholism or drug abuse, or long-term use of benzodiazepines or opioids. 3.Patients with adverse reactions to the anesthetics used in the study. 4.Patients with infection at the puncture site or coagulation dysfunction. 5.Patients with diabetes mellitus or severe organic dysfunction of vital organs. 6.Patients who refuse any part of the study: e.g., refusing to complete preoperative and postoperative scale assessments, or refusing the anesthetic regimen specified in the study. 7.Patients with severe organic diseases (including coronary heart disease, atrioventricular block of degree ? or higher, bradycardia (HR < 50 beats/min), hypotension (SBP < 90 mmHg), bronchial asthma, severe hypertension, severe hematological dysfunction, hepatic/renal/cerebral dysfunction, gastric emptying disorders, gastroparesis, and significant electrolyte imbalance).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Numeric Pain Rating Scale (NRS) Scores at Rest at 2, 4, 8, 16, 24, and 48 Hours After Surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of rescue analgesia administrations within 48 hours after surgery;Total Number of PCIA Administrations;Number of Effective PCIA Administrations;Incidence of Postoperative Adverse Reactions (Including Respiratory Depression, Nausea and Vomiting, Somnolence, Pruritus, etc.);Evaluation of Postoperative Analgesia Satisfaction Within 48 Hours After Surgery;Time to First Ambulation After Surgery; | — |
Countries
China
Contacts
Public ContactYang Li
The Second People's Hospital of Yibin City
Outcome results
None listed