Laparoscopic Cholecystectomy
Conditions
Interventions
Esketamine Group:Intravenous injection of esketamine (0.25 mg/kg) was administered 3 minutes prior to skin incision
Control Group:An equivalent volume of normal saline was intravenously administered 3 minutes prior to skin incision
Sponsors
Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-65 years old (including the boundary values); 2. Patients scheduled for elective day-case laparoscopic cholecystectomy; 3. American Society of Anesthesiologists (ASA) classification I-II; 4. Able to understand and complete the QoR-15 questionnaire independently; 5. Voluntarily participating in this study and signing the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients who have experienced pain before surgery for any reason and those taking analgesics; 2. Severe cardiovascular or pulmonary diseases (such as decompensated heart failure, severe chronic obstructive pulmonary disease); 3. Allergic to esketamine or related anesthetics; 4. Patients with a high risk of hypertension or increased intracranial pressure; 5. Patients with poorly controlled or untreated hypertension; 6. Patients with untreated or inadequately treated hyperthyroidism; 7. Severe liver, kidney, neurological, or metabolic diseases; 8. History of psychiatric disorders or long-term use of antipsychotic drugs; 9. Vulnerable populations, including individuals with psychiatric disorders, cognitive impairments, critically ill patients, pregnant women, illiterate individuals, etc.; 10. Other conditions that the investigator believes make the subject unsuitable for participation in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total QoR-15 Score on the First Postoperative Day; | — |
Secondary
| Measure | Time frame |
|---|---|
| Total preoperative QoR-15 score;Dimension-specific QoR-15 scores on the first postoperative day;Visual Analogue Scale (VAS) pain scores at rest and during movement in the Post-Anesthesia Care Unit (PACU), at 6 hours postoperatively, and at discharge;Blood pressure and heart rate before anesthesia, at 5 minutes after tracheal intubation, at 5 minutes after tracheal extubation, upon discharge from PACU, and at hospital discharge;Post-Anesthesia Recovery (PAR) score in the PACU;PACU length of stay;Time to first postoperative ambulation (h);Adverse events, including nausea, vomiting, shoulder pain, myalgia, and psychiatric symptoms such as dizziness and hallucinations;Day-case clinical pathway completion rate; | — |
Countries
China
Contacts
Public ContactChen Gang
Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University
Outcome results
None listed