Stroke
Conditions
Interventions
Control group:iTBS sham stimulation + BCI
Experimental group 1:M1-iTBS+BCI
Experimental group 2:DLPFC+M1-iTBS+BCI
Sponsors
Longgang District People's Hospital of Shenzhen
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients diagnosed with stroke confirmed by CT or MRI; 2. Patients with unilateral hemiplegia after their first stroke, with a course of stroke >1 week; or patients with recurrent stroke who had no sequelae from the first stroke, but now have unilateral hemiplegia, with a course of stroke >1 week; 3. Accompanied by moderate to severe hand dysfunction (Brunnstrom <= Grade 4, MAS <= Grade 3); 4. No severe cognitive impairment and able to perform hand grasping and other movements following instructions; 5. No severe cardiovascular, pulmonary, liver, or kidney dysfunction, no history of drug or alcohol dependence, or other serious diseases affecting brain structure and function, and no severe psychiatric disorders; 6. Able to sit independently or with support for more than 1 hour and voluntarily willing to participate.
Exclusion criteria
Exclusion criteria: 1. History of two or more strokes with residual effects; 2. Presence of limb dysfunction caused by other reasons before onset; 3. Complicated with severe cardiopulmonary, liver, kidney, or hematological complications; 4. Other neurological diseases, inability to cooperate with training, or poor treatment adherence; 5. Cognitive impairments, or visual or hearing impairments; 6. Sensory aphasia or mixed aphasia affecting patient communication; 7. Unstable fractures, infections, or active bleeding in the affected hand; 8. History of seizures in the past three months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Upper Limb Fugl-Meyer Assessment (FMA-UE);Activities of Routine Activities Test (ARAT);Wolf Motor Function Test (WMFT) Score;Modified Barthel Index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Near-infrared brain functional imaging to detect changes in hemoglobin concentration;Blood Oxygen Level Dependent Magnetic Resonance Imaging (BOLD-fMRI);Diffusion tensor imaging(DTI);Resting-state electroencephalogram (EEG) and event-related desynchronisation (ERD) characteristics; | — |
Countries
China
Contacts
Public ContactBenguo Wang
Longgang District People's Hospital of Shenzhen
Outcome results
None listed