Global developmental delay
Conditions
Interventions
Low-frequency group:Conventional rehabilitation therapy + low-frequency (6Hz) high-precision transcranial alternating current stimulation (HD-tACS)
High-Frequency Group:Conventional rehabilitation therapy + high-frequency (40Hz) high-precision transcranial alternating current stimulation (HD-tACS)
Control group:Conventional rehabilitation therapy + High-Definition Transcranial Alternating Current Stimulation (HD-tACS) (no actual electrical current)
Sponsors
The Third Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
2 Years to 5 Years
Inclusion criteria
Inclusion criteria: 1 Age: 24 to 60 months; 2 Meets DSM-5 diagnostic criteria for global developmental delay; 3 GDS assessment: Scores below 75 in two or more domains, including the adaptive skills domain; 4 Parent or guardian consents to study participation, completes pre-treatment evaluations, and signs informed consent form.
Exclusion criteria
Exclusion criteria: 1 Individuals with motor disorders such as cerebral palsy or spinal cord injury; 2 Patients with severe hearing or visual impairments, or other conditions affecting assessment; 3 Those with epilepsy or other severe neurological disorders; 4 Patients with identifiable causes of developmental delay, such as postnatal encephalitis, traumatic brain injury, cerebral hemorrhage, or confirmed diagnoses of genetic metabolic disorders or neurodegenerative diseases; 5 Patients with cardiac pacemakers or other electronic implants; 6 Patients with metallic implants or intracranial metal fragments; 7 Patients who have recently undergone other brain stimulation therapies; 8 Patients with allergies or contraindications to electrical stimulation therapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gesell Developmental Scale ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Electroencephalogram assessment;fNIRS ; | — |
Countries
China
Contacts
Public ContactDengna Zhu
The Third Affiliated Hospital of Zhengzhou University
Outcome results
None listed