Hypotension and Hypoxemia During Gastrointestinal Endoscopy
Conditions
Interventions
Ciprofol Group:A loading dose of 0.3 mg/kg ciprofol was administered intravenously over a minimum period of 30 seconds.
Propofol Group:A loading dose of 1.5 mg/kg propofol was administered intravenously over a minimum period of 30 seconds.
Sponsors
Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 65 years; 2. Planning to undergo elective digestive endoscopy with sedation; 3. American Society of Anesthesiologists (ASA) classification I–III; 4. Pre-procedure pulse oxygen saturation (SpO2) in room air >= 93%; 5. Voluntarily participating in this study and signing the informed consent form. If the subject is unable to read or sign the informed consent due to lack of capacity, the consent process must be conducted by their guardian, who will sign the informed consent on their behalf.
Exclusion criteria
Exclusion criteria: 1. Emergency endoscopic examination; 2. Severe cardiovascular or pulmonary diseases (such as decompensated heart failure, severe chronic obstructive pulmonary disease); 3. Baseline systolic blood pressure <90 mmHg or heart rate <50 beats/min; 4. Allergies to remimazolam, propofol, or opioids; 5. Anticipated difficult airway or severe obesity; 6. Severe liver, kidney, neurological, or metabolic diseases; 7. History of alcohol or drug abuse; 8. Vulnerable populations other than the elderly, including individuals with mental illness, cognitive impairment, critically ill patients, pregnant women, illiterate individuals, etc.; 9. Other conditions that the investigator considers make the subject unsuitable for participation in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| hypoxemia;hypotension;Sedation Induction Time; | — |
Secondary
| Measure | Time frame |
|---|---|
| incidence of hypoxemia alone;incidence of hypotension alone;Incidence of Airway Interventions (e.g., Jaw Thrust, Oropharyngeal/Nasopharyngeal Airway Insertion, Assisted Ventilation);Usage of Vasoactive Drugs;Endoscopist Satisfaction;Patient Satisfaction;Total Dosage of Sedative Drugs;PACU Discharge Time;Time to Full Consciousness (MOAA/S = 5); | — |
Countries
China
Contacts
Public ContactChen Gang
Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University
Outcome results
None listed