locally advanced resectable oral squamous cell carcinoma and oropharyngeal squamous cell carcinoma
Conditions
Interventions
Observation group:None
Sponsors
Zhujiang Hospital of Southern Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Pathological diagnosis of oral squamous cell carcinoma or oropharyngeal squamous cell carcinoma; 2. According to AJCC criteria (8th edition), diagnosed with locally advanced disease (stage III/IVA oral cancer or HPV-negative oropharyngeal cancer, stage II/III HPV-positive oropharyngeal cancer) and assessed by the investigator as surgically resectable; 3. Age 18-80 years; 4. Blood routine: white blood cell count >= 3×10^9/L, platelet count >= 75×10^9/L; hemoglobin concentration >= 80 g/L; 5. Liver function: AST and ALT 50 ml/min; 7. Major organs such as heart, lungs, thyroid, and overall condition capable of tolerating the study treatment regimen; 8. Signed informed consent.
Exclusion criteria
Exclusion criteria: 1.Pregnancy or lactation (for female participants); 2.A history of epilepsy or mental illness that is not effectively controlled; 3.Unresolved toxicities of grade > 2 per CTCAE criteria resulting from prior anticancer therapy; 4.Other conditions deemed unsuitable for study participation by the investigators, including patients with autoimmune diseases or those at high risk of bleeding due to various causes.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Objective Response Rate,ORR; | — |
Secondary
| Measure | Time frame |
|---|---|
| two-year event-free survivall rate;Tumor regression pattern; | — |
Countries
China
Contacts
Public ContactLv Xiaozhi
Zhujiang Hospital of Southern Medical University
Outcome results
None listed