None listed
Conditions
Interventions
Induction Group:The Biased Coin Design (BCD) method was employed, starting from the initial dose and continuing until the study conclusion.
Fospropofol disodium group:Administered using the research results from Part 1 (ED95), via slow intravenous injection, with completion of administration within 60 seconds.
Propofol group:Adverse reactions
Sponsors
The Fourth People's Hospital of Guiyang City
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Patients aged >=65 years scheduled for elective surgery under general anesthesia; (2) ASA class II–III, Mallampati class I–II, BMI 18–30 kg/m²; (3) No history of allergy to anesthetic drugs; (4) No severe organ dysfunction, endocrine disorders, or metabolic diseases.
Exclusion criteria
Exclusion criteria: (1) Patients with a history of difficult airway or assessed preoperatively as difficult intubation; (2) Patients with a history of psychiatric disorders or long-term use of sedative/analgesic medications; (3) Patients with severe cardiovascular or pulmonary diseases; (4) Patients with severe hepatic or renal insufficiency; (5) Patients allergic to the investigational drug or its components; (6) Patients with long-term alcohol abuse; (7) Patients with abnormal preoperative alkaline phosphatase levels.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ED50, ED95;?PRD;? dT°; | — |
Secondary
| Measure | Time frame |
|---|---|
| mean arterial pressure, MAP;heart rate, HR;Adverse reactions;Anesthesia induction time;Anesthesia induction success rate; | — |
Countries
China
Contacts
Public ContactYanqiu Liu
The Fourth People's Hospital of Guiyang City
Outcome results
None listed