Diabetic kidney disease ( DKD )
Conditions
Interventions
The diabetes nephropathy group (DKD) with high levels of PCSK9 and angptl3:None
Type 2 diabetes mellitus without concurrent diabetic nephropathy group:None
The diabetes nephropathy group (DKD) with low levels of PCSK9 and angptl3:none
Sponsors
The Affiliated Hospital of Southwest Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Age 18-80 years; 2.According to the diagnostic criteria of type 2 diabetes mellitus, DKD was consistent with the diagnostic criteria of diabetic nephropathy ( diabetes history >=1 year, urinary protein / creatinine ratio ( UACR ) >= 30 mg / g or abnormal serum creatinine level, and renal damage caused by other reasons was excluded ). 3.There were complete clinical data, including baseline laboratory examination and follow-up data.
Exclusion criteria
Exclusion criteria: 1.Patients with type 1 diabetes and special types of diabetes; 2.Patients with other endocrine system diseases, such as Cushing 's syndrome, polycystic ovary syndrome, hyperthyroidism and uncorrected hypothyroidism, etc. 3.Patients with severe liver dysfunction; 4.Chronic kidney disease patients without diabetic nephropathy and DKD patients receiving hemodialysis or kidney transplantation. 5.Pregnant and lactating women;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lipid metabolism indicators ( PCSK9, angptl3 );Blood lipids ( including total cholesterol, triglyceride, low density lipoprotein cholesterol, high density lipoprotein cholesterol, etc. );Liver and kidney function (including serum creatinine, blood urea nitrogen, blood uric acid, estimated glomerular filtration rate, total bile acid, etc.);Glucose Metabolism Indicators (Fasting Blood Glucose, Glycated Hemoglobin);Incidence of >=50% Decline in eGFR Rate;The incidence rate of progressing to end-stage renal disease; | — |
Secondary
| Measure | Time frame |
|---|---|
| All-Cause Mortality;Incidence of Cardiovascular Complications (including myocardial infarction, stroke, and angina); | — |
Countries
China
Contacts
Public ContactWu Weihua
The Affiliated Hospital of Southwest Medical University
Outcome results
None listed