Acute cerebral infarction
Conditions
Interventions
Experimental group:Drug intervention was carried out to regulate blood pressure until the cerebral blood flow rate reached the normal level. The upper and lower limits were set at 180 mmHg and 100 mmH
Sponsors
The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital)
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Adult patients, aged 18 - 80 years old; 2. Confirmed large vessel occlusion in the anterior circulation; 3. After treatment, vascular reconstruction and reperfusion degree is at level IIB - III; 4. Before the onset, the modified Rankin Scale (mRS) score was 0 - 2 points;
Exclusion criteria
Exclusion criteria: 1. Posterior circulation stroke; 2. Congenital anatomical abnormalities in the neck and intracranial major arteries; 3. Presence of untreated severe internal carotid artery stenosis or occlusion; 4. Post-vascular-intervention imaging confirmed that the ischemic penumbra could not be saved, or severe brain swelling, even high pressure and other serious secondary conditions occurred; 5. Unstable vital signs, requiring the use of vasoactive drugs to maintain blood pressure (norepinephrine greater than 0.1ug/kg.min); 6. Patients with heart dysfunction or coagulation disorders;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quantitative electroencephalogram indicators;Cerebral tissue oxygen saturation (rSO2); | — |
Secondary
| Measure | Time frame |
|---|---|
| The NIHSS score;CT ASPECT Score;Edema score ;Days of mechanical ventilation;GCS-M score;MRS score;Length of stay in the ICU;Length of hospital stay;Blood sugar;Blood lipid;Neuron-specific enolase; | — |
Countries
China
Contacts
Public ContactLiu Haiyan/You Heyang
The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital)
Outcome results
None listed