Idiopathic Pulmonary Fibrosis, IPF
Conditions
Interventions
Gold Standard:Pathologically confirmed UIP type
Index test:The UIP-specific diagnostic model that captures the multi-gene, multi-protein signature of the "pathological niche," and develop a dynamic framework for gauging fibrotic activity.
Sponsors
State Key Laboratory of Respiratory Disease, National Clinical Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: a) IPF diagnosis can be definitively established through clinical symptoms, laboratory tests, and imaging findings reviewed by a multidisciplinary team (MDT); b) After MDT discussion, lung biopsy is deemed unnecessary for a conclusive IPF diagnosis; c) Following initial MDT review, histopathological assessment (e.g., SLB or TBLC) is performed and a second MDT conference confirms fulfillment of IPF diagnostic criteria; d) The patient voluntarily enrolls in the study and provides written informed consent.
Exclusion criteria
Exclusion criteria: a) ILD of known alternative etiology (e.g., connective-tissue disease, occupational/environmental exposure, drug toxicity); b) Co-existent severe systemic disorders (e.g., advanced heart failure, end-stage renal disease, active malignancy) with an expected survival <1 year; c) Pregnancy or lactation; d) Inability to provide informed consent or to comply with follow-up procedures; e) Any other condition that, in the investigator’s judgment, renders the participant unsuitable for enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mortality rate;Significant decline in lung function;Accuracy; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sensitivity;Specificity; | — |
Countries
China
Contacts
Public ContactQun Luo
the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health
Outcome results
None listed