Leptomeningeal Metastasis (LM)
Conditions
Interventions
Prophylactic Intraventricular Vancomycin group:(1) Preparation of Lock Solution: Under a laminar airflow hood, preservative-free normal saline is used to dilute vancomycin powder to a final concentrat
Control group:In the control group, after each intraventricular chemotherapy drug infusion, 4 ml of tube-sealing fluid (or normal saline) was injected at a constant speed through the OmR using an inje
Sponsors
Nanjing Brain Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Diagnosed with meningeal metastasis (according to the European Neuro-Oncology Society standards); 2. Planned to receive the first Ommaya reservoir intraventricular chemotherapy; 3. Assessed by a previously established risk prediction model and determined to be a high-risk patient for Ommaya reservoir-related meningitis; 4. Life expectancy >= 6 months.
Exclusion criteria
Exclusion criteria: 1. Allergic to vancomycin antibiotics; 2. Infection occurred after Ommaya reservoir implantation and before chemotherapy; 3. Presence of a ventriculoperitoneal shunt; 4. Severe renal dysfunction; 5. Severe coagulation disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ommaya Reservoir–Associated Meningitis; | — |
Secondary
| Measure | Time frame |
|---|---|
| Vancomycin-related adverse events (renal function [creatinine, blood urea nitrogen], hearing, allergic reactions);Length of hospital stay;Hospitalization medical expenses; | — |
Countries
China
Contacts
Public ContactFang Shencun
Nanjing Brain Hospital
Outcome results
None listed