Advanced non-small cell lung cancer with oligometastasis in a stable phase
Conditions
Interventions
Local ablation combined with systemic therapy group:Localized ablation
standard systemic therapy group:Pure standard systemic therapy
Sponsors
People's Hospital of Leshan
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1.According to the 9th edition TNM staging of the International Association for the Study of Lung Cancer (IASLC), clinically diagnosed as stage IIIB-IV (including patients whose lung cancer recurred or metastasized after early postoperative patients who did not receive adjuvant therapy); 2.Confirmed as non-small cell lung cancer by cytology or tissue biopsy, with oligometastatic disease, having fewer than 5 systemic metastatic lesions; 3.Receive standard systematic treatment, including chemotherapy, immunotherapy, or targeted therapy; 4.The patient is in a stable phase of the disease, that is, having used targeted therapy continuously for 2 months or chemotherapy drugs continuously for 2 cycles. 5.Eastern Cooperative Oncology Group Performance Status (ECOG PS) score of 0–2; 6.After evaluation by the physician, the patient agrees to undergo local ablation therapy, including any one of argon-helium knife treatment, radiofrequency ablation treatment, or radioactive particle implantation treatment, and has signed the informed consent form; 7.After evaluation by the physician, the patient agreed to undergo bronchial artery infusion chemotherapy embolization (TACE) and signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1.The patient has a serious hematologic disorder. 2.Patients in the progressive stage of the disease. 3.History of other types of malignant tumors. 4.Combined with other serious underlying conditions, such as uncontrolled arrhythmias, severe cardiac dysfunction, respiratory failure, severe liver dysfunction and cirrhosis, chronic kidney disease, etc. 5.Those with incomplete medical records.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Progression-free survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| Overall survival; | — |
Countries
China
Contacts
Public Contactluowei
People's Hospital of Leshan
Outcome results
None listed