Gastrointestinal diseases
Conditions
Interventions
A group: After the administration of remifentanil, inject the assigned dose of ciprofol within 30 seconds,the dose of ciprofol for the next patient will be determined based on the response of the pre
B group: After the administration of remifentanil, inject the assigned dose of ciprofol within 30 seconds, the dose of ciprofol for the next patient will be determined based on the response of the pr
Sponsors
The First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients over 65 years old planning to undergo painless gastroscopy under intravenous anesthesia; 2. American Society of Anesthesiologists (ASA) class I-III; 3. BMI between 18 and 28 kg/m^2; 4. Able to understand the study protocol and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Acute upper gastrointestinal bleeding with shock; 2. Known allergy to eggs, soy products, milk, or drugs such as propofol; 3. Obstructive sleep apnea; 4. Acute upper respiratory tract infection within 1 week, or asthma attack; 5. Uncontrolled severe hypertension; 6. Severe anemia; 7. Severe liver or kidney dysfunction; 8. Gastrointestinal obstruction with retention of stomach contents; 9. History of alcoholism or drug dependence.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 50% Effective Dose of Ciprofol; | — |
Secondary
| Measure | Time frame |
|---|---|
| Systolic pressure;Diastolic pressure;Mean arterial pressure;Heart rate;SpO2;Induction time;Examination time;Awakening time;PACU stay time;Adverse events ; | — |
Countries
China
Contacts
Public ContactYang Jian
The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed