Obesity
Conditions
Interventions
non-obese group,:Patients within each group were randomly assigned to receive one of five doses of remimazolam tosylate — 0.07, 0.12, 0.17, 0.22, or 0.27 mg·kg-1 — for anesthesia induction.
obese group:Patients within each group were randomly assigned to receive one of five doses of remimazolam tosylate — 0.07, 0.12, 0.17, 0.22, or 0.27 mg·kg-1 — for anesthesia induction.
Sponsors
The First Affiliated Hospital, Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1 ASA physical status I–III; 2 Age 18–60 years; 3 Patients scheduled for elective surgery;
Exclusion criteria
Exclusion criteria: 1 Patients undergoing liver resection or liver transplantation with a history of liver disease (history of liver disease, total bilirubin > 3.0 mg/dL, or aspartate aminotransferase/alanine aminotransferase > 2.5 times the upper limit of normal); 2 Renal disease (serum creatinine > 2 mg/dL); 3 Poorly controlled hypertension (e.g., systolic blood pressure > 160 mmHg despite antihypertensive therapy); 4 Diabetes mellitus (glycated hemoglobin > 9%); 5 Intolerance or allergy to benzodiazepines/GABA-A receptor agonists; 6 History of substance abuse; 7 Glaucoma; 8 Heart failure; 9 Peripheral arterial disease; 10 Chronic obstructive pulmonary disease (COPD); 11 Patients scheduled for regional anesthesia prior to induction; 12 Pregnant women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ED95 of LoC ;Mean arterial pressure; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of respiratory depression;the time to onset of RD;Narcotrend index;Heart rate ; | — |
Countries
China
Contacts
Public ContactXia Feng
The First Affiliated Hospital, Sun Yat-sen University
Outcome results
None listed