Amyotrophic Lateral Sclerosis
Conditions
Interventions
ALS patient group:Add high-energy nutritional supplementation (Fresubin 53.8 g/day, providing approximately 970 kcal, 8.6 g protein, and 7.6 g fat) to standard diet (energy: 25–30 kcal/kg/day, protein
Sponsors
China Rehabilitation Research Center (Beijing Bo'ai Hospital)
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Confirmed diagnosis of ALS. 2. Aged between 18 and 75 years (inclusive). 3. Normal digestive function and tolerance to enteral nutrition. 4. Willing and able to comply with medical instructions and complete the treatment protocol.
Exclusion criteria
Exclusion criteria: 1. History of gastrointestinal surgery that impairs digestive or absorptive function. 2. Portal hypertension due to esophageal or gastric varices. 3. Concurrent other diseases that may affect body composition.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Muscle mass, body fat percentage, and ALS FRS-R score; | — |
Secondary
| Measure | Time frame |
|---|---|
| NRS2002 nutritional screening score, GLIM malnutrition assessment score, GUSS score, expiratory/inspiratory score; | — |
Countries
China
Contacts
Public ContactLu Haitao
China Rehabilitation Research Center (Beijing Bo'ai Hospital)
Outcome results
None listed