Postoperative Pulmonary Complications
Conditions
Interventions
Driving pressure-guided lung protective ventilation:Driving pressure-guided positive end-expiratory pressure (PEEP) titration
Electrical impedance tomography (EIT)-guided lung protective ventilation:EIT-guided PEEP titration
Sponsors
National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 18 to 80 years; 2. American Society of Anesthesiologists (ASA) physical status 26.
Exclusion criteria
Exclusion criteria: 1. History of previous thoracic or abdominal surgery; 2. Pulmonary infection within the last three months (or severe pulmonary disease/chronic obstructive pulmonary disease); 3. Allergy or contraindication to sevoflurane, propofol, or nonsteroidal anti-inflammatory drugs (NSAIDs); 4. Body mass index (BMI) > 40 kg/m²; 5. Emergency surgery; 6. Severe cerebral or cardiovascular dysfunction; 7. Suspected or diagnosed immune or neuromuscular disorders; 8. Anticipated need for prolonged postoperative mechanical ventilation; 9. Liver cirrhosis (Child–Pugh class B or C); 10. Chronic renal failure requiring dialysis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative pulmonary complications within 30 postoperative days; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative ventilation mechanics;Intraoperative EIT parameters;Lung aeration parameters on postoperative day 3;Level of serum lung injury biomarker;Level of serum inflammatory factor;Numeric rating scale of pain;Surgical rating scale;Postoperative length of hospitalization;Length of stay in post-anesthesia care unit;Postoperative nausea and vomiting;Gastrointestinal recovery time; | — |
Countries
China
Contacts
Public ContactYan Tao
National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Outcome results
None listed